The journey with semaglutide has been transformative, but challenging. Having been on this medication for weight loss for the past year, I have encountered numerous side effects. However, with the right coping strategies and an open dialogue with my healthcare team, I've learned to overcome the hurdles and stay focused on my goals.
The Most Common Side Effects
According to clinical trials, the most frequently reported side effects of semaglutide include nausea, diarrhea, vomiting, constipation, and abdominal pain. During my first few months, I experienced periods of nausea and an upset stomach. After some trial and error, I finally found a routine that was effective for me.
My Personal Experience and Coping Strategies

For me, the nausea was worst if I took semaglutide on an empty stomach first thing in the morning. I started taking my dose with a small, bland snack like plain crackers or a piece of toast and it made a huge difference. I also slowly injected the injection feeling like it was helping with my nausea, it may just be a placebo effect. On days when I still felt queasy, sipping ginger or peppermint tea provided relief,as well as the provided anti-nausea pills.
The gastrointestinal side effects were also tough at times. I learned to adjust my diet, avoiding heavy, greasy, or overly spicy foods on treatment days. Staying well hydrated and incorporating probiotic foods like yogurt helped keep things regulated. I did have some constipation, but nothing that I would say is unbearable.
Finding What Works for You
What's important to remember is that side effects can vary from person to person. You may experience entirely different issues or have an easier time overall. Pay attention to your body's signals, and don't be afraid to experiment a bit with timing, diet, and routine to pinpoint what works best.
Working With Your Healthcare Team
Open and honest communication with your prescribing doctor is essential for managing any side effects. At my monthly check-ins, I give a candid account of what I've been experiencing - both the good and the bad. My doctor has been able to adjust my dosage, suggest coping mechanisms, or switch me to alternative medications if needed based on my personal reaction.
You're Not Alone
If you're struggling with side effects, please know that you're not alone. Connect with others taking semaglutide through online support groups or patient community forums. Sharing tips, stories, and words of encouragement can make a world of difference on tough days.
Semaglutide has the potential to be life-changing for many when it comes to weight loss and improved metabolic health. But every person's experience will be unique. By listening to your body, adapting as needed, and maintaining open communication with your medical team, you can navigate side effects and stay on track towards your goals.
Sarah B., 2024